anti- PBX1 antibody

Product Description

anti- PBX1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the(1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex(PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression(By similarity)..

Immunogen: pre-B-cell leukemia homeobox 1

Synonyms: PRL

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IP

Recommended dilution:

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Image 4: A2780 cells were subjected to SDS PAGE followed by western blot with FNab06182(PBX1 antibody) at dilution of 1:500

Gene ID: 5087

Research Area: Metabolism

Uniprot ID: P40424