anti- PHAX antibody

Product Description

anti- PHAX antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex(CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs(snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner(By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA(snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated(TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA..

Immunogen: phosphorylated adaptor for RNA export

Synonyms: RNUXA

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab06372(PHAX antibody) at dilution of 1:800

Gene ID: 51808

Research Area: Metabolism

Uniprot ID: Q9H814