anti- PHF2 antibody

Product Description

anti- PHF2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA..

Immunogen: PHD finger protein 2

Synonyms: GRC5, JHDM1E, KIAA0662, PHD finger protein 2, PHF2

Reactivity: Human

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:200-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab06384(PHF2 Antibody) at dilution of 1:50

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab06384(PHF2 Antibody) at dilution of 1:500

Gene ID: 5253

Research Area: Metabolism

Uniprot ID: O75151