anti- phospho(409/410)-TDP43 antibody

Product Description

anti- phospho(409/410)-TDP43 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409/410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa..

Immunogen: TAR DNA binding protein

Synonyms: phospho TDP43, phospho(409/410)-TDP43, TARDBP, TDP43

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500-1:2000

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Image 4: human placenta tissue were subjected to SDS PAGE followed by western blot with FNab06401(phospho(409/410)-TDP43 antibody) at dilution of 1:1000

Gene ID: 23435

Research Area: Metabolism

Uniprot ID: Q13148