anti- PIAS1 antibody

Product Description

anti- PIAS1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma(IFN-gamma) signaling. Sumoylates PML(at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation(By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity)..

Immunogen: protein inhibitor of activated STAT, 1

Synonyms: DDXBP1

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06428(PIAS1 antibody) at dilution of 1:2000

Gene ID: 8554

Research Area: Metabolism

Uniprot ID: O75925