anti- Piezo1 antibody

Product Description

anti- Piezo1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity)..

Immunogen: family with sequence similarity 38, member A

Synonyms: FAM38A, KIAA0233

Reactivity: Human, Mouse

Tested Application: ELISA, WB,IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human brain tissue slide using FNab06435(FAM38A Antibody) at dilution of 1:200

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06435(Piezo1 antibody) at dilution of 1:500

Gene ID: 9780

Research Area: Metabolism

Uniprot ID: Q92508