anti- PIF1 antibody

Product Description

anti- PIF1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex(G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks(DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity..

Immunogen: PIF1 5'-to-3' DNA helicase homolog(S. cerevisiae)

Synonyms: C15orf20

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab06436(PIF1 antibody) at dilution of 1:800

Gene ID: 80119

Research Area: Metabolism

Uniprot ID: Q9H611