anti- PIN1 antibody

Product Description

anti- PIN1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Peptidyl-prolyl cis/trans isomerase(PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro(pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins(PubMed:21497122, PubMed:22033920). Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK(PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation(PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner(PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN(PubMed:22608923)..

Immunogen: peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human renal cell carcinoma tissue slide using FNab06457(PIN1 Antibody) at dilution of 1:50

Image 2: .

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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab06457(PIN1 antibody) at dilution of 1:1000

Gene ID: 5300

Research Area: Metabolism

Uniprot ID: Q13526