anti- PPP4R2 antibody

Product Description

anti- PPP4R2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Regulatory subunit of serine/threonine-protein phosphatase 4(PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140'(gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair..

Immunogen: protein phosphatase 4, regulatory subunit 2

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab06734(PPP4R2 Antibody) at dilution of 1:50

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Image 4: A549 cells were subjected to SDS PAGE followed by western blot with FNab06734(PPP4R2 antibody) at dilution of 1:1000

Gene ID: 151987

Research Area: Metabolism

Uniprot ID: Q9NY27