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Product Description
anti- PRKAR1A antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed..
Immunogen: protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
Synonyms: PKR1, PRKAR1, TSE1
Reactivity: Human
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Image 1: Immunohistochemistry of paraffin-embedded human oophoroma using FNab06779(PRKAR1A antibody) at dilution of 1:100
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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab06779(PRKAR1A antibody) at dilution of 1:1000
Gene ID: 5573
Research Area: Metabolism
Uniprot ID: P10644
