anti- PRKG1 antibody

Product Description

anti- PRKG1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity..

Immunogen: protein kinase, cGMP-dependent, type I

Synonyms: PRKG1B, PRKGR1A, PRKGR1B

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded mouse lung using FNab06786(PRKG1 antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06786(PRKG1 antibody) at dilution of 1:1000

Gene ID: 5592

Research Area: Metabolism

Uniprot ID: Q13976