anti- PRR5 antibody

Product Description

anti- PRR5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer..

Immunogen: proline rich 5(renal)

Synonyms: PROTOR1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human placenta using FNab06830(PRR5 antibody) at dilution of 1:100

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Image 4: human kidney tissue were subjected to SDS PAGE followed by western blot with FNab06830(PRR5 antibody) at dilution of 1:500

Gene ID: 55615

Research Area: Metabolism

Uniprot ID: P85299