anti- PSME3 antibody

Product Description

anti- PSME3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Subunit of the 11S REG-gamma(also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring(PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978)..

Immunogen: proteasome(prosome, macropain) activator subunit 3(PA28 gamma; Ki)

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer using FNab06896(PSME3 antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: human colon tissue were subjected to SDS PAGE followed by western blot with FNab06896(PSME3 antibody) at dilution of 1:500

Gene ID: 10197

Research Area: Metabolism

Uniprot ID: P61289