anti- PTP1B antibody

Product Description

anti- PTP1B antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene..

Immunogen: protein tyrosine phosphatase, non-receptor type 1

Synonyms: PTP 1B, PTP1B, PTPN1

Reactivity: Human, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded rat kidney using FNab10253(PTP1B antibody) at dilution of 1:50

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Image 4: jurkat cells were subjected to SDS PAGE followed by western blot with FNab10253(PTP1B antibody) at dilution of 1:1000

Gene ID: 5770

Research Area: Metabolism

Uniprot ID: P18031