anti- PTPRJ antibody

Product Description

anti- PTPRJ antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET(variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor(TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells(APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling..

Immunogen: protein tyrosine phosphatase, receptor type, J

Synonyms: DEP1

Reactivity: Human

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab06945(PTPRJ antibody) at dilution of 1:500

Gene ID: 5795

Research Area: Metabolism

Uniprot ID: Q12913