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Product Description
anti- RANKL antibody is available at Gentaur for Next week Delivery.
Purification: Protein A+G purification
Background: TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis..
Immunogen: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoprotegerin ligand, RANKL, sOdf, TNFSF11, TRANCE
Reactivity: Human
Tested Application: ELISA, WB
Recommended dilution: WB: 1:1000-1:5000
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Image 4: Hela cells were subjected to SDS PAGE followed by western blot with FNab09838(RANKL antibody) at dilution of 1:3000
Gene ID: 8600
Research Area: Metabolism
Uniprot ID: O14788
