anti- RRP8 antibody

Product Description

anti- RRP8 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown..

Immunogen: ribosomal RNA processing 8, methyltransferase, homolog(yeast)

Synonyms: KIAA0409, NML

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human skin using FNab07501(RRP8 antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab07501(RRP8 antibody) at dilution of 1:1500

Gene ID: 23378

Research Area: Metabolism

Uniprot ID: O43159