anti- RSPO3 antibody

Product Description

anti- RSPO3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity)..

Immunogen: R-spondin 3 homolog

Synonyms: CRISTIN1, hPWTSR, hRspo3, Protein with TSP type 1 repeat, PWTSR, R spondin 3, Roof plate specific spondin 3, RSPO3, THSD2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:100-1:400

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab07512(RSPO3 Antibody) at dilution of 1:200

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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab07512(RSPO3 Antibody) at dilution of 1:300

Gene ID: 84870

Research Area: Metabolism

Uniprot ID: Q9BXY4