anti- RXRA antibody

Product Description

anti- RXRA antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements(RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements(RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes..

Immunogen: retinoid X receptor, alpha

Synonyms: NR2B1

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution: WB: 1:200-1:1000

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab07543(RXRA antibody) at dilution of 1:100

Gene ID: 6256

Research Area: Metabolism

Uniprot ID: P19793