anti- SART3 antibody

Product Description

anti- SART3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation(PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites(PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly(PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair(PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC(By similarity)..

Immunogen: squamous cell carcinoma antigen recognized by T cells 3

Synonyms: DSAP1, hSART 3, KIAA0156, P100, p110, p110(nrb), RP11 13G14, SART 3, SART3, TIP110,

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab07612(SART3 antibody) at dilution of 1:100

Image 2: .

Image 3: IP Result of anti-SART3 (IP: FNab07612, 4ug; Detection: FNab07612 1:800) with HeLa cells lysate 2000ug.

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab07612(SART3 antibody) at dilution of 1:1000

Gene ID: 9733

Research Area: Metabolism

Uniprot ID: Q15020