anti- SESN1 antibody

Product Description

anti- SESN1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway(PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses(By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1(PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein(By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed(By similarity)..

Immunogen: sestrin 1

Synonyms: PA26,

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab07759(SESN1 antibody) at dilution of 1:500

Gene ID: 27244

Research Area: Metabolism

Uniprot ID: Q9Y6P5