anti- SETD7 antibody

Product Description

anti- SETD7 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation..

Immunogen: SET domain containing(lysine methyltransferase) 7

Synonyms: KIAA1717, KMT7, SET7, SET9

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab07769( SETD7 Antibody) at dilution of 1:1000

Gene ID: 80854

Research Area: Metabolism

Uniprot ID: Q8WTS6