anti- SH2D1B antibody

Product Description

anti- SH2D1B antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule(SLAM) family such as CD84, SLAMF1, LY9 and CD244(PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer(NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation(PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling(By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse(PubMed:24687958). Negatively regulates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation(By similarity)..

Immunogen: SH2 domain containing 1B

Synonyms: EAT2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab07820(SH2D1B Antibody) at dilution of 1:200

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07820(SH2D1B antibody) at dilution of 1:800

Gene ID: 117157

Research Area: Metabolism

Uniprot ID: O14796