anti- SHP2 antibody

Product Description

anti- SHP2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: PTPN11(protein tyrosine phosphatase, non-receptor type 11) is also named as PTP-1D, PTP2, PTP2C, PTP3, SHP2, CFC, CFC, BPTP3, SH-PTP2, SH-PTP3, MGC14433 and belongs to the protein-tyrosine phosphatase family and non-receptor class 2 subfamily. It modulates and regulates signaling through numerous pathways, many of which are active in the developing endocardial cushions and implicated the ERK pathway as a central mechanism(PMID:19017799). Its signaling may play equally important roles in retinal survival in both physiological and pathological conditions(PMID:21576358). Defects in PTPN11 are the cause of LEOPARD syndrome type 1(LEOPARD1), Noonan syndrome type 1(NS1), juvenile myelomonocytic leukemia(JMML) and metachondromatosis(MC). It has 3 isoforms produced by alternative splicing..

Immunogen: protein tyrosine phosphatase, non-receptor type 11

Synonyms: BPTP3, CFC, NS1, PTP 1D, PTP 2C, PTP2C, PTPN11, SH PTP2, SH PTP3, SHP 2, SHP2, SHPTP2

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution: WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab07854(PTPN11 antibody) at dilution of 1:100

Image 2: Immunofluorescent analysis of Hela cells, using FNab07854(PTPN11 antibody)at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red)..

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab07854(PTPN11 antibody) at dilution of 1:500

Gene ID:

Research Area: Metabolism

Uniprot ID: Q06124