anti- SIGLEC7 antibody

Product Description

anti- SIGLEC7 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-and alpha-2,6-linked sialic acid. Also binds disialogangliosides(disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells(in vitro)..

Immunogen: sialic acid binding Ig-like lectin 7

Synonyms: AIRM1

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human tonsillitis slide using FNab07862(SIGLEC7 Antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: U-937 cells were subjected to SDS PAGE followed by western blot with FNab07862(SIGLEC7 antibody) at dilution of 1:1000

Gene ID: 27036

Research Area: Metabolism

Uniprot ID: Q9Y286