anti- SIX1 antibody

Product Description

anti- SIX1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2(By similarity). Regulates the expression of CCNA1..

Immunogen: SIX homeobox 1

Synonyms:

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IF, IP

Recommended dilution:

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Image 4: A2780 cells were subjected to SDS PAGE followed by western blot with FNab07886(SIX1 antibody) at dilution of 1:800

Gene ID: 6495

Research Area: Metabolism

Uniprot ID: Q15475