anti- SMARCE1 antibody

Product Description

anti- SMARCE1 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling(alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex(npBAF complex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes(nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth(By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases(HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells..

Immunogen: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Synonyms: BAF57

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08015(SMARCE1 Antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08015(SMARCE1 Antibody) at dilution of 1:1000

Gene ID: 6605

Research Area: Metabolism

Uniprot ID: Q969G3