anti- SMC1A antibody

Product Description

anti- SMC1A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms..

Immunogen: structural maintenance of chromosomes 1A

Synonyms: DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20 - 1:100; IP : 1:50 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab08016(SMC1A antibody) at dilution of 1:200

Image 2: Immunofluorescence analysis of U2OS cells using FNab08016(SMC1A antibody) at dilution of 1:50.

Image 3:

Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab08016(SMC1A antibody) at dilution of 1:1000

Gene ID: 8243

Research Area: Metabolism

Uniprot ID: Q14683