anti- SNAPIN antibody

Product Description

anti- SNAPIN antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles(LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells(PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor(PubMed:25898167)..

Immunogen: SNAP-associated protein

Synonyms: BLOC1S7, SNAP25BP, SNAPAP

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IF, WB, IHC, FC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08060(SNAPIN Antibody) at dilution of 1:200

Image 2: .

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Image 4: rat brain tissue were subjected to SDS PAGE followed by western blot with FNab08060(SNAPIN Antibody) at dilution of 1:200

Gene ID: 23557

Research Area: Metabolism

Uniprot ID: O95295