anti- SNX27 antibody

Product Description

anti- SNX27 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate(PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes..

Immunogen: sorting nexin family member 27

Synonyms: KIAA0488

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab08090(SNX27 Antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08090(SNX27 antibody) at dilution of 1:1200

Gene ID: 81609

Research Area: Metabolism

Uniprot ID: Q96L92