anti- SOCS3 antibody

Product Description

anti- SOCS3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo(By similarity). Probable substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST(By similarity)..

Immunogen: suppressor of cytokine signaling 3

Synonyms: CIS3, SSI3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IF, IP

Recommended dilution: WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human heart using FNab08100(SOCS3 antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HepG2 cells, using FNab08100(SOCS3 antibody)at 1:10 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye)..

Image 3: IP Result of anti-SOCS3 (IP:FNab08100,4ug; Detection: FNab08100 1:500) with K-562 cells lysate 1720ug.

Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab08100(SOCS3 antibody) at dilution of 1:500

Gene ID: 9021

Research Area: Metabolism

Uniprot ID: O14543