anti- SP100 antibody

Product Description

anti- SP100 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation..

Immunogen: SP100 nuclear antigen

Synonyms:

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor using FNab08132(SP100antibody) at dilution of 1:50

Image 2: .

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08132(SP100 antibody) at dilution of 1:400

Gene ID: 6672

Research Area: Metabolism

Uniprot ID: P23497