anti- SRGAP2 antibody

Product Description

anti- SRGAP2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia..

Immunogen: SLIT-ROBO Rho GTPase activating protein 2

Synonyms: ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human kidney slide using FNab08225(SRGAP2 Antibody) at dilution of 1:50

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Image 4: mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab08225(SRGAP2 antibody) at dilution of 1:1000

Gene ID: 23380

Research Area: Metabolism

Uniprot ID: O75044