anti- Synaptotagmin-1 antibody

Product Description

anti- Synaptotagmin-1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis(PMID: 8058779). SYT1(synaptotagmin I) was firstly identified as a 65-kDa protein with a wide distribution in neuronal and neurosecretory tissue(PMID: 7298720). Calcium binding to SYT1 participates in triggering neurotransmitter release at the synapse(PMID: 11242035). In addition to regulating exocytosis, SYT1 has also been implicated in endocytosis and neurite outgrowth(PMID: 15492212; 11078930; 10336114). This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1..

Immunogen: synaptotagmin I

Synonyms: DKFZp781D2042, P65, SVP65, Synaptotagmin 1, synaptotagmin I, SYT, SYT1, SytI

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer using FNab08425(SYT1 antibody) at dilution of 1:100

Image 2: Immunofluorescent analysis of ( -20? Ethanol) fixed HepG2 cells using FNab08425 (Synaptotagmin-1 antibody) at dilution of 1:50 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: human liver tissue were subjected to SDS PAGE followed by western blot with FNab08425(SYT1 antibody) at dilution of 1:1000

Gene ID:

Research Area: Metabolism

Uniprot ID: P21579