anti- SYVN1 antibody

Product Description

anti- SYVN1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis..

Immunogen: synovial apoptosis inhibitor 1, synoviolin

Synonyms: HRD1, KIAA1810

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab08463(HRD1 Antibody) at dilution of 1:200

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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab08463(SYVN1 antibody) at dilution of 1:1000

Gene ID: 84447

Research Area: Metabolism

Uniprot ID: Q86TM6