anti- TAP1 antibody

Product Description

anti- TAP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules..

Immunogen: transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)

Synonyms: ABCB2, PSF1, RING4, Y3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IF, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab08499(TAP1 Antibody) at dilution of 1:50

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08499(TAP1 Antibody) at dilution of 1:1000

Gene ID: 6890

Research Area: Metabolism

Uniprot ID: Q03518