anti- TDG antibody

Product Description

anti- TDG antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine(5fC) and 5-carboxylcytosine(5caC) in the context of CpG sites and mediates their excision through base-excision repair(BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine(5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil(5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine..

Immunogen: thymine-DNA glycosylase

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution:

Image 1:

Image 2: .

Image 3:

Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab08570(TDG antibody) at dilution of 1:400

Gene ID: 6996

Research Area: Metabolism

Uniprot ID: Q13569