anti- THOC2 antibody

Product Description

anti- THOC2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production. THOC2(and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development..

Immunogen: THO complex 2

Synonyms: CXorf3

Reactivity: Human

Tested Application: ELISA, IP, WB, IF

Recommended dilution:

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab08667(THOC2 Antibody) at dilution of 1:300

Gene ID: 57187

Research Area: Metabolism

Uniprot ID: Q8NI27