anti- THRAP3 antibody

Product Description

anti- THRAP3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex(EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons(PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes(PubMed:24043798)..

Immunogen: thyroid hormone receptor associated protein 3

Synonyms: TRAP150

Reactivity: Human

Tested Application: ELISA, WB, IF, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab08673(THRAP3 Antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab08673(THRAP3 antibody) at dilution of 1:500

Gene ID: 9967

Research Area: Metabolism

Uniprot ID: Q9Y2W1