anti- TICAM2 antibody

Product Description

anti- TICAM2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes..

Immunogen: toll-like receptor adaptor molecule 2

Synonyms: TIRAP3, TIRP, TRAM

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08687(TICAM2 Antibody) at dilution of 1:50

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Image 4: PC-3 cells were subjected to SDS PAGE followed by western blot with FNab08687(TICAM2 antibody) at dilution of 1:500

Gene ID: 353376

Research Area: Metabolism

Uniprot ID: Q86XR7