anti- TNF-alpha antibody

Product Description

anti- TNF-alpha antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer..

Immunogen: tumor necrosis factor(TNF superfamily, member 2)

Synonyms: Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNFSF2, Tumor necrosis factor

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC,WB

Recommended dilution: WB: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab08821(TNF-a Antibody) at dilution of 1:50

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Image 4: mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab08821(TNFA antibody) at dilution of 1:300

Gene ID:

Research Area: Metabolism

Uniprot ID: P01375