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Product Description
anti- TOP1MT antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone(By similarity)..
Immunogen: topoisomerase(DNA) I, mitochondrial
Synonyms:
Reactivity: Human
Tested Application: ELISA, WB
Recommended dilution:
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Image 4: COLO 320 cells were subjected to SDS PAGE followed by western blot with FNab08866(TOP1MT Antibody) at dilution of 1:1000
Gene ID: 116447
Research Area: Metabolism
Uniprot ID: Q969P6
