anti- TOP3A antibody

Product Description

anti- TOP3A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity..

Immunogen: topoisomerase(DNA) III alpha

Synonyms: TOP3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recommended dilution:

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Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab08870(TOP3A antibody) at dilution of 1:1000

Gene ID: 7156

Research Area: Metabolism

Uniprot ID: Q13472