anti- TP53INP1 antibody

Product Description

anti- TP53INP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species(ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC..

Immunogen: tumor protein p53 inducible nuclear protein 1

Synonyms: P53DINP1, SIP

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab08879(TP53INP1 antibody) at dilution of 1:50

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Gene ID:

Research Area: Metabolism

Uniprot ID: Q96A56