anti- TRAF6 antibody

Product Description

anti- TRAF6 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells(DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1(AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production..

Immunogen: TNF receptor-associated factor 6

Synonyms: RNF85

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human colon tissue slide using FNab08921(TRAF6 Antibody) at dilution of 1:200

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Image 4: A431 cells were subjected to SDS PAGE followed by western blot with FNab08921(TRAF6 antibody) at dilution of 1:300

Gene ID: 7189

Research Area: Metabolism

Uniprot ID: Q9Y4K3