anti- TRAIP antibody

Product Description

anti- TRAIP antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4-and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation(By similarity)(PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase(PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity(PubMed:24553286). The function in translesion synthesis is controversial(PubMed:26595769)..

Immunogen: TRAF interacting protein

Synonyms: RNF206, TRIP

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab08924(TRAIP Antibody) at dilution of 1:200

Image 2: Immunofluorescent analysis of HepG2 cells using FNab08924 (TRAIP antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab08924(TRAIP antibody) at dilution of 1:1000

Gene ID: 10293

Research Area: Metabolism

Uniprot ID: Q9BWF2