anti- TRPM5 antibody

Product Description

anti- TRPM5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Voltage-modulated Ca(2+)-activated, monovalent cation channel(VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals..

Immunogen: transient receptor potential cation channel, subfamily M, member 5

Synonyms: LTrpC 5, LTRPC5, MTR1, TRPM5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:1000; IF: N/A

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Image 4: mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab09021(TRPM5 antibody) at dilution of 1:1000

Gene ID: 29850

Research Area: Metabolism

Uniprot ID: Q9NZQ8