anti- TXNIP antibody

Product Description

anti- TXNIP antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1)..

Immunogen: thioredoxin interacting protein

Synonyms: EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, TXNIP, VDUP1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB, IF

Recommended dilution: WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab09129(TXNIP Antibody) at dilution of 1:200

Image 2: Immunofluorescent analysis of HeLa cells using FNab09129 (TXNIP antibody) at dilution of 1:25 and Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L).

Image 3: IP Result of anti-TXNIP (IP: FNab09129, 4ug; Detection: FNab09129 1:500) with K-562 cells lysate 4000ug.

Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab09129(TXNIP Antibody) at dilution of 1:600

Gene ID: 10628

Research Area: Metabolism

Uniprot ID: Q9H3M7