anti- UBE2K antibody

Product Description

anti- UBE2K antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation(ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1..

Immunogen: ubiquitin-conjugating enzyme E2K

Synonyms: DKFZp564C1216, DKFZp686J24237, E2-25K, HIP 2, HIP2, HYPG, LIG, UBE2K, Ubiquitin carrier protein, Ubiquitin protein ligase

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab09178(UBE2K antibody) at dilution of 1:50

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab09178(UBE2K antibody) at dilution of 1:500

Gene ID: 3093

Research Area: Metabolism

Uniprot ID: P61086