anti- Ubiquilin 1 antibody

Product Description

anti- Ubiquilin 1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1..

Immunogen: ubiquilin 1

Synonyms: DA41, DSK2, FLJ90054, hPLIC 1, PLIC 1, PLIC1, ubiquilin 1, UBQLN1, XDRP1

Reactivity: Human, Rat

Tested Application: ELISA, IHC, WB, IF

Recommended dilution: WB: 1:200-1:1000; IF: 1:10-1:100; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human pancreas slide using FNab09196(UBQLN1 Antibody) at dilution of 1:50

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Image 4: rat brain tissue were subjected to SDS PAGE followed by western blot with FNab09196(Ubiquilin 1 Antibody) at dilution of 1:300

Gene ID:

Research Area: Metabolism

Uniprot ID: Q9UMX0